Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia

Winer P., Muskens IS., Walsh KM., Vora A., Moorman AV., Wiemels JL., Roberts I., Roy A., de Smith AJ.

<jats:title>Key Points</jats:title> <jats:p>Rare and pathogenic germline variants, including in IKZF1, contribute to acute lymphoblastic leukemia in children with Down syndrome.</jats:p>

DOI

10.1182/bloodadvances.2019001216

Type

Journal article

Journal

Blood Advances

Publisher

American Society of Hematology

Publication Date

21/02/2020

Volume

4

Pages

672 - 675

Original publication