Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks.

Song W., Ramadan K.

In this issue of Molecular Cell, Rahmanto et al.1 and Zhao et al.2 demonstrate that RNA-protein crosslinks contribute to formaldehyde toxicity by blocking protein synthesis. Furthermore, they identify a ubiquitin-mediated degradation system for RNA-protein crosslink resolution in eukaryotes.

DOI

10.1016/j.molcel.2023.11.009

Type

Journal article

Publication Date

2023-12-07T00:00:00+00:00

Volume

83

Pages

4197 - 4199

Total pages

2

Keywords

Adenosine Triphosphatases, Cell Cycle Proteins, Proteasome Endopeptidase Complex, RNA, Ubiquitin, Valosin Containing Protein

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