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X-linked lymphoproliferative disease (XLP) is triggered by Epstein-Barr virus. This virus is also associated with Burkitt lymphoma, a tumor that carries specific chromosome translocations. No such chromosome translocations have been observed in an analysis of XLP-derived cell lines. One XLP patient was found also to have Klinefelter syndrome, having inherited two copies of his maternal XLP-carrying X chromosome.

Original publication

DOI

10.1159/000132516

Type

Journal article

Journal

Cytogenet Cell Genet

Publication Date

1988

Volume

47

Pages

92 - 94

Keywords

Cell Line, Disease Susceptibility, Herpesvirus 4, Human, Humans, Karyotyping, Klinefelter Syndrome, Lymphoproliferative Disorders, Male, Pedigree, Tumor Virus Infections, X Chromosome