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Two studies were carried out (A and B) in order to assess the effectiveness of ifosfamide administered with mesna (IFO/M) in the treatment of small cell lung cancer. The first study (A) was a cross-over study; the second (B) was a randomized trial, and in B IFO/M was evaluated earlier in the course of the disease. IFO/M given be infusion is effective as second-line therapy and can be administered with other cytotoxics at the doses reported here earlier in the course of the disease. The complete remission rates were high.

Original publication

DOI

10.1007/BF00647447

Type

Journal article

Journal

Cancer Chemother Pharmacol

Publication Date

1986

Volume

18 Suppl 2

Keywords

Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Small Cell, Drug Evaluation, Humans, Ifosfamide, Infusions, Intravenous, Lung Neoplasms, Mercaptoethanol, Mesna