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Multiple leakage of lysosomal enzymes from cystic fibrosis fibroblasts into the extracellular space has been suggested to occur but was not observed in these experiments. Both extracellular and intracellular levels of enzyme activity were within the normal range. The release of lysosomal enzymes from individual cell lines was seen to be affected both by intrinsic properties of each cell line and by many external factors.

Original publication

DOI

10.1111/j.1399-0004.1981.tb01039.x

Type

Journal article

Journal

Clin Genet

Publication Date

10/1981

Volume

20

Pages

315 - 319

Keywords

Adolescent, Adult, Cell Line, Child, Cystic Fibrosis, Extracellular Space, Fibroblasts, Humans, Hydrolases