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The effect of the dose of aminoglutethimide on the suppression of oestrone, oestradiol and dehydroepiandrosterone sulphate (DHAS) levels was studied in 36 women with advanced postmenopausal breast cancer, all of whom received 20 mg hydrocortisone twice daily as replacement glucocorticoid. Aminoglutethimide (AG) 250 mg twice a day was as effective as AG 250 mg 3 times a day or AG 250 mg 4 times a day. Side-effects were less at the lowest dosage and were age-related. On-treatment oestrone levels were higher in non-responders to treatment. Lower doses of AG than are currently used may be as effective therapeutically.

Original publication

DOI

10.1016/0277-5379(83)90112-8

Type

Journal article

Journal

Eur J Cancer Clin Oncol

Publication Date

04/1983

Volume

19

Pages

493 - 498

Keywords

Adult, Aged, Aminoglutethimide, Breast Neoplasms, Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate, Drug Administration Schedule, Drug Therapy, Combination, Estradiol, Estrone, Female, Gonadal Steroid Hormones, Humans, Hydrocortisone, Menopause, Middle Aged