Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

WNT-2 is a secreted polypeptide with mitogenic effects in murine mammary epithelial cells, but its role in human cancer is unknown. Using RNase protection analysis of primary cell preparations and in situ hybridization analysis, we report that WNT-2 is expressed at low levels in normal human breast fibroblasts but not in epithelial cells. WNT-2 was found to be expressed at high levels in both the epithelium and stroma of 5 of 11 infiltrating carcinomas and 2 of 6 fibroadenomas. The high level of WNT-2 expression in tumor epithelium suggests that tumorigenesis may involve the ectopic expression of WNT-2 and the creation of an autocrine Wnt signaling loop.

Type

Journal article

Journal

Cancer Res

Publication Date

01/10/1996

Volume

56

Pages

4320 - 4323

Keywords

Breast, Breast Neoplasms, Carcinoma, Ductal, Breast, Connective Tissue, Epithelium, Female, Fibroadenoma, Fibroblasts, Gene Expression Regulation, Neoplastic, Humans, In Situ Hybridization, Neoplasm Proteins, Proto-Oncogene Proteins, Signal Transduction, Wnt2 Protein