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Serum aspartate transaminase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (gamma GT) activities and the serum ALP isoenzyme pattern have been measured in eleven patients undergoing treatment with CB3717. There were increases in the activity of all three enzymes. The ALP isoenzyme pattern showed an increased contribution of the intestinal isoenzyme to the serum ALP activity. This may be due to increased intestinal mucosal leakage or impaired uptake and breakdown of the intestinal isoenzyme by the liver.

Original publication

DOI

10.1002/jso.2930380205

Type

Journal article

Journal

J Surg Oncol

Publication Date

06/1988

Volume

38

Pages

83 - 87

Keywords

Adult, Aged, Alkaline Phosphatase, Aspartate Aminotransferases, Female, Folic Acid, Humans, Intestinal Mucosa, Isoenzymes, Liver Neoplasms, Male, Middle Aged, Quinazolines, Time Factors, gamma-Glutamyltransferase