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By means of a cytokine release assay we have shown that in cell populations derived from primary breast carcinoma, epidermal growth factor (EGF) is secreted by cells with the characteristic morphological and immunophenotypic profile of activated macrophages (positive for CD68, CD16, CD25). EGF secretion was observed in 11 (31%) of 35 primary tumours. Secretion of EGF by normal or malignant epithelial cells was not observed. We found no association between EGF secretion by the primary tumour and recognised clinical indices of prognosis.

Original publication

DOI

10.1016/0140-6736(93)91348-p

Type

Journal article

Journal

Lancet

Publication Date

17/07/1993

Volume

342

Pages

148 - 149

Keywords

Adult, Aged, Aged, 80 and over, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Epidermal Growth Factor, Epithelium, Female, Humans, Immunophenotyping, Leukocyte Common Antigens, Macrophage Activation, Macrophages, Middle Aged