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Identification of dendritic cells (DC) in human tissues has been technically problematic due to the lack of truly specific immunohistochemical markers for DC's. Human dendritic cells express CD1a glycoprotein at certain points in their life cycle. CD1a positive cells are present in many human tumours and have been associated with improved survival. However, little information exists concerning the separation of DC from human tumours. The current study reports that human breast carcinomas have low densities of CD1a positive cells with dendritic morphology, and details are shown of a technique for successful separation of these cells from tumour tissues.

Original publication

DOI

10.1007/978-1-4757-9966-8_92

Type

Conference paper

Publication Date

1997

Volume

417

Pages

571 - 577

Keywords

Antigen Presentation, Antigens, CD1, Breast Neoplasms, Carcinoma, Ductal, Breast, Cell Count, Cell Separation, Dendritic Cells, Female, Humans, Lymphocytes, Tumor-Infiltrating, T-Lymphocytes