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Primary fibromyalgia syndrome (PFS) is a non-articular rheumatic condition characterized by chronic muscular pain. We have performed screening for autoantibodies in 20 women with PFS and in 19 age-matched healthy women. Fifty-five percent of the PFS patients had anti-smooth muscle antibodies and 40% had anti-striated muscle antibodies. None of the control subjects had any muscle antibodies. There was no significant difference in frequency of the remaining autoantibodies between the groups investigated. The present study indicates autoimmune responses in PFS against antigens of the diseased tissue itself, a finding which may be secondary to the disease or have relevance to the still obscure pathogenesis of the syndrome.

Original publication

DOI

10.1111/j.1699-0463.1990.tb04984.x

Type

Journal article

Journal

APMIS

Publication Date

07/1990

Volume

98

Pages

655 - 658

Keywords

Autoantibodies, Enzyme-Linked Immunosorbent Assay, Female, Fibromyalgia, Fluorescent Antibody Technique, Hemagglutination Tests, Humans, Middle Aged, Radioimmunoassay, Reference Values, Syndrome