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In 200 patients, 143 women and 57 men, with rheumatoid arthritis (RA), age at onset was related to the presence of IgM rheumatoid factor (RF) and antinuclear antibodies (ANA) in serum at presentation. The patients were stratified into bands of age at onset: <40 years, 40- 60 years, and >60 years. In women, the prevalences of ANA (1:160) were 63.0%, 45.5%, and 31.1% in the respective age bands ( p=0.002), and the prevalences of IgM RF were 85.2%, 72.7% and 66.4%, respectively ( p=0.03). The prevalences of ANA and IgM RF among men were, respectively, 35% and 86% with no association with age at onset. The findings may indicate interactive effects between gender and various pathogenetic factors.

Original publication

DOI

10.1007/s10067-003-0844-9

Type

Journal article

Journal

Clin Rheumatol

Publication Date

04/2004

Volume

23

Pages

121 - 122

Keywords

Adult, Age of Onset, Antibodies, Antinuclear, Arthritis, Rheumatoid, Denmark, Female, Humans, Immunoglobulin M, Male, Middle Aged, Rheumatoid Factor