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DNA was extracted from tissue samples of three unrelated cases of insulinoma. Chromosome 11 allele loss was investigated using several chromosome 11 specific probes which detect restriction fragment length polymorphisms. In one case, which proved informative for many of the chromosome 11 markers, allele loss was shown on both 11p and 11q. This finding is of considerable interest as the allele loss closely corresponds to that recently reported in insulinomas occurring in the familial multiple endocrine neoplasia type 1 (MEN-1) syndrome.

Original publication

DOI

10.1136/jcp.43.5.377

Type

Journal article

Journal

J Clin Pathol

Publication Date

05/1990

Volume

43

Pages

377 - 378

Keywords

Adenoma, Islet Cell, Alleles, Blotting, Southern, Chromosome Aberrations, Chromosome Disorders, Chromosome Mapping, Chromosomes, Human, Pair 11, Humans, Insulinoma, Pancreatic Neoplasms