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A cDNA for the neurotransmitter-degrading enzyme monoamine oxidase-A (MAO-A) has been assigned by in situ hybridization to the human X chromosome and subregionally localized to Xp11.23-11.4. As restriction fragments detected by this probe are deleted in some patients with Norrie disease, this assignment provides confirmation of the localization of the disease.

Original publication

DOI

10.1016/0888-7543(89)90072-4

Type

Journal article

Journal

Genomics

Publication Date

08/1989

Volume

5

Pages

368 - 370

Keywords

Chromosome Banding, Chromosome Mapping, Humans, Monoamine Oxidase, Nucleic Acid Hybridization, X Chromosome