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Cloned human telomeric DNA can integrate into mammalian chromosomes and seed the formation of new telomeres. This process occurs efficiently in three established human cell lines and in a mouse embryonic stem cell line. The newly seeded telomeres appear to be healed by telomerase. The seeding of new telomeres by cloned telomeric DNA is either undetectable or very inefficient in non-tumourigenic mouse or human somatic cell lines. The cytogenetic consequences of the seeding of new telomeres include large chromosome truncations but most of the telomere seeding events occur close to the pre-existing ends of natural chromosomes.

Original publication

DOI

10.1093/nar/21.1.27

Type

Journal article

Journal

Nucleic Acids Res

Publication Date

11/01/1993

Volume

21

Pages

27 - 36

Keywords

Animals, Base Sequence, Cell Line, Chromosomes, Chromosomes, Human, Cloning, Molecular, DNA, HeLa Cells, Humans, In Situ Hybridization, Karyotyping, Mice, Molecular Sequence Data, Telomere