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T cell receptor (TCR) down-regulation is a consequence of specific receptor engagement and plays an important role in modulating the T cell response. We have investigated the role of protein kinase C (PKC) and protein tyrosine kinases (PTK) in the induction of TCR down-regulation. We report that the mutation of S126 in the CD3-gamma chain that is known to inhibit phorbol-12-myristate 13-acetate-induced TCR down-regulation does not affect down-regulation induced by a specific agonist. In addition, agonist-induced TCR down-regulation is not affected by blockade or depletion of PKC, neither by blockade or lack of PTK, while the same treatments efficiently interfere with T cell activation. These results demonstrate that TCR down-regulation is induced by early events which follow specific engagement by an agonist and can be dissociated from those required for full T cell activation.

Original publication




Journal article


Eur J Immunol

Publication Date





1769 - 1773


CD3 Complex, Down-Regulation, Enzyme Activation, Humans, Jurkat Cells, Lymphocyte Activation, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Protein Kinase C, Protein-Tyrosine Kinases, Receptors, Antigen, T-Cell, T-Lymphocytes, Tetradecanoylphorbol Acetate, src-Family Kinases