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Monoclonal antibodies to epithelial-cell antigenic determinants, labelled with 123I and 125I, were administered parenterally to immunodeficient mice bearing human tumours derived from a human cancer cell line. Anterior, posterior and lateral radioscans of the body were taken with a gamma scintillation camera at various times from immediately to 65 days after injection. Visual displays of the images were processed by standard computer techniques. The model used a human colon-cancer cell line, HT29, and the monoclonal antibody, AUA1, which is specific to an epithelial proliferating antigen. Tumour detection was achieved in all the mice. The smallest tumour detectable appeared to be about 1 mm in diameter. The degree of antibody uptake in a tumour depended on its size and the blood supply of its surrounding tissues We believe that the technology and skills are now available for accurate radioimmunodetection of cancer in man.

Original publication

DOI

10.1038/bjc.1982.157

Type

Journal article

Journal

Br J Cancer

Publication Date

07/1982

Volume

46

Pages

1 - 8

Keywords

Animals, Antibodies, Monoclonal, Antibodies, Neoplasm, Cell Line, Disease Models, Animal, Humans, Iodine Radioisotopes, Mice, Mice, Inbred BALB C, Neoplasms, Experimental, Radionuclide Imaging