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A monoclonal antibody (H17E2) against placental alkaline phosphatase (PLAP) and testicular placental-like alkaline phosphatase was labelled with indium-111 and used in radioimmunoscintigraphy of 15 patients known or suspected to have germ-cell carcinoma of the testis or carcinoma of the ovary or cervix. Good images of neoplastic lesions were obtained in most patients with active disease. In 1 patient with testicular teratoma and elevated human chorionic gonadotropin who had a normal computed tomography scan, the labelled antibody located microscopic disease in a lymph node, which was then removed. No false positive localisation was seen in patients with PLAP-negative tumours or sites of inflammation. This method may be helpful in the diagnosis, staging, and monitoring of PLAP-positive neoplasms of testicular, ovarian, and cervical origin.

Original publication

DOI

10.1016/s0140-6736(85)92495-x

Type

Journal article

Journal

Lancet

Publication Date

17/08/1985

Volume

2

Pages

350 - 353

Keywords

Adult, Aged, Alkaline Phosphatase, Antibodies, Monoclonal, Clinical Enzyme Tests, Female, Humans, Indium, Male, Middle Aged, Ovarian Neoplasms, Placenta, Pregnancy, Radioisotopes, Radionuclide Imaging, Testicular Neoplasms, Testis, Uterine Cervical Neoplasms