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A long-range restriction map encompassing the APC (adenomatous polyposis coli) gene has been constructed. The map includes 35 DNA markers and consists of two segments of 10 and 2.5 Mb. Published genetic markers have been connected using additional, nonpolymorphic DNA probes. The map clarifies marker order and allows comparison of physical and genetic data.

Original publication

DOI

10.1006/geno.1993.1277

Type

Journal article

Journal

Genomics

Publication Date

07/1993

Volume

17

Pages

15 - 24

Keywords

Adenomatous Polyposis Coli, Chromosomes, Fungal, Chromosomes, Human, Pair 5, Cosmids, DNA Probes, Gene Library, Genetic Markers, Genome, Human, Humans, In Situ Hybridization, Fluorescence, Polymorphism, Restriction Fragment Length, Restriction Mapping