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© 2013 Elsevier Inc. All rights reserved. This LIM domain was first described in the LIM homeodomain transcription factor Mec-3 in Caenorhabditis elegans, and named following the identification of two further proteins which share the LIM domain, that is, L(in-11), I(sl1), and M(ec-3). Unlike LIM homeodomain proteins, the LIM domain-only (LMO) proteins lack an obvious DNA-binding element and instead associate with DNA-binding proteins. The LMO family comprises four highly conserved members. Each member of the LIM-only family is involved in transcription regulation controlling normal differentiation processes and in cancer by abnormal expression, in three cases (LMO1, 2, and 3) via chromosomal translocations.

Original publication





Book title

Brenner's Encyclopedia of Genetics: Second Edition

Publication Date



264 - 266