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Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate cancer, are critical to cancer cell proliferation and tumor growth. In this review we focused on the cross-talk between hormone and hypoxia pathways, particularly in breast cancer. We delineated a novel signaling pathway from estrogen receptor to hypoxia-inducible factor 1, and discussed the role of this pathway in endocrine therapy resistance. Further, we discussed the estrogen and hypoxia pathways converging at histone demethylase KDM4B, an important epigenetic modifier in cancer.

Original publication

DOI

10.3390/ijms19010240

Type

Journal article

Journal

Int j mol sci

Publication Date

13/01/2018

Volume

19

Keywords

KDM4B, endocrine therapy resistance, estrogen receptor alpha, hypoxia-inducible factor 1