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The molecular response of cancer cells to hypoxia is the focus of intense research. In the last decade, research into microRNAs (miRNAs), small RNAs which have a role in regulation of mRNA and translation, has grown exponentially. miR-210 has emerged as the predominant miRNA regulated by hypoxia. Elucidation of its targets points to a variety of roles for this, and other hypoxia-regulated miRNAs (HRMs), in tumour growth and survival. miR-210 expression correlates with poor survival in cancer patients, and shows promise for future use as a tumour marker or therapeutic agent. The role of miR-210 and other HRMs in cancer biology is the subject of this review.

Original publication

DOI

10.1007/82_2010_76

Type

Journal article

Journal

Curr Top Microbiol Immunol

Publication Date

2010

Volume

345

Pages

47 - 70

Keywords

Cell Hypoxia, Humans, Iron-Sulfur Proteins, MicroRNAs, Mitochondria, Neoplasms, Protein Biosynthesis, RNA, Messenger