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We have investigated the subnuclear localisation of the protein product of the c-myc oncogene. We show that, although c-myc is not present in the nuclear skeleton or matrix II fraction, it is associated with the nuclear matrix I fraction which is a complex group of proteins implicated in physiological processes within the nucleus. The interaction of the c-myc protein and the matrix I fraction is through a specific metal interaction and presumably, therefore, represents the in vivo location of this protein.


Journal article


Oncogene Res

Publication Date





221 - 228


Carcinoma, Small Cell, Cell Line, Cell Nucleus, Copper, Humans, Lung Neoplasms, Protein Binding, Proto-Oncogene Proteins, Proto-Oncogenes