Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Three CD3 genes, gamma, delta, epsilon, map to human chromosome 11 band q23. A 75-kb region of 11q23 containing all three genes has been characterized by field inversion gel electrophoresis and molecular cloning. The CD3 genes lie within a stretch of 50 kb of DNA, orientated 3'-CD3 gamma-5': 5'-CD3 delta-3': 3'-CD3 epsilon-5'. Only 1.6 kb separate the CD3 gamma and CD3 delta genes, while the CD3 delta and CD3 epsilon genes are approximately 22 kb apart. CD3 gene expression is one of the first events during the maturation of the thymocyte, and therefore the clustering of CD3 genes may define a chromatin domain which is activated early in T cell development.

Original publication




Journal article


Eur J Immunol

Publication Date





1639 - 1642


Antigens, Differentiation, T-Lymphocyte, CD3 Complex, Chromosomes, Human, Pair 11, Cloning, Molecular, Electrophoresis, Agar Gel, Genes, Humans, Receptors, Antigen, T-Cell, Restriction Mapping