Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A mouse cloned cDNA probe containing a variable (V) region belonging to the VHIII subgroup has been used in filter hybridisations to estimate the number of heavy-chain V-genes in this subgroup of mouse and human DNA. There seem to be about 10 and 20 VH-genes hybridising to this probe in mouse and human DNA, respectively. Studies of cross-hybridisation of the related VK-genes from MOPC21 and MPC11 myelomas indicate that the experiments detect all members of the VHIII subgroup.


Journal article



Publication Date





238 - 243


Animals, Antibody Diversity, Base Sequence, Binding Sites, Antibody, Genes, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Immunoglobulin kappa-Chains, Mice, Nucleic Acid Hybridization, Structure-Activity Relationship