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The search for tumour-specific markers is one of the chief goals in cancer biology. We show that the translocation t(12;16)(q13:p11) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene, FUS, which can result in fusion of the FUS glycine-rich protein with the whole CHOP coding region. The data support the concept that protein fusion may commonly occur in solid tumours resulting in tumour-specific markers of potential clinical importance. The data also indicate the importance of transcription disruption in the pathogenesis of solid tumours.

Original publication




Journal article


Nat Genet

Publication Date





175 - 180


Amino Acid Sequence, Base Sequence, CCAAT-Enhancer-Binding Proteins, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 16, DNA, DNA, Neoplasm, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Genes, Dominant, Heterogeneous-Nuclear Ribonucleoproteins, Humans, Liposarcoma, Molecular Sequence Data, Neoplasm Proteins, Nuclear Proteins, Polymerase Chain Reaction, RNA-Binding Protein FUS, Ribonucleoproteins, Transcription Factor CHOP, Transcription Factors, Transcription, Genetic, Translocation, Genetic