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MOTIVATION: Coalescent-based simulation software for genomic sequences allows the efficient in silico generation of short- and medium-sized genetic sequences. However, the simulation of genome-size datasets as produced by next-generation sequencing is currently only possible using fairly crude approximations. RESULTS: We present the sequential coalescent with recombination model (SCRM), a new method that efficiently and accurately approximates the coalescent with recombination, closing the gap between current approximations and the exact model. We present an efficient implementation and show that it can simulate genomic-scale datasets with an essentially correct linkage structure.

Original publication

DOI

10.1093/bioinformatics/btu861

Type

Journal article

Journal

Bioinformatics

Publication Date

15/05/2015

Volume

31

Pages

1680 - 1682

Keywords

Algorithms, Computer Simulation, Genetic Linkage, Genomics, High-Throughput Nucleotide Sequencing, Models, Genetic, Recombination, Genetic, Software