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The HLA--Bw4 and Bw6 antigenic determinants have been shown to co-migrate with HLA--B determinants on gel-filtration, sucrose density gradient centrifugation and affinity chromatography, using Lens culinaris lectin and antibody against human beta 2 microbulin. These and other published data imply that the HLA--Bw4 and Bw6 determinants reside on the same polypeptide chain as other HLA--B locus determinants. The implications of this in terms of the evolution of cross reacting groups of antigens at the HLA--B locus are discussed.

Original publication

DOI

10.1111/j.1399-0039.1979.tb00805.x

Type

Journal article

Journal

Tissue Antigens

Publication Date

05/1979

Volume

13

Pages

334 - 341

Keywords

Biological Evolution, Cell Membrane, Centrifugation, Density Gradient, Chromatography, Affinity, Chromatography, Gel, Chromosome Mapping, Cross Reactions, Epitopes, HLA Antigens, Humans, Lymphocytes, beta 2-Microglobulin