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A simple method to estimate the mean fitness of human translocation carriers is described. The method is based on information about the inheritance pattern of the translocations. This kind of data can be obtained from the surveys of the chromosome constitutions of new-born babies. The following fitness estimates are obtained: D/D translocation carriers, 0-94; D/G translocation carriers, 0-83; and reciprocal translocation carriers, 0-67. The estimates are rather uncertain due to the scarcity of information, but they are consistent with the expected results. More accurate estimates will be obtained in the future when more data on translocation carriers are available and the cytological classification of the different translocations becomes more exact.

Type

Journal article

Journal

Ann Hum Genet

Publication Date

11/1976

Volume

40

Pages

253 - 257

Keywords

Biological Evolution, Chromosome Aberrations, Fertility, Humans, Infant, Newborn, Life Expectancy, Translocation, Genetic