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Rabbit sera used as a complement source contain cytotoxic antibodies which reacted with cultured human cells. This cytotoxic activity can be inhibited by human IgM. The capacity of IgM mu and L chains, and IgM glycopeptides to inhibit these heterospecific antibodies was determined. The inhibitory activity of several monosaccharides, bacterial polysaccharides and blood group substances was also determined. At least some of the heterospecific antibodies in normal rabbit sera are directed against carbohydrate determinants. Mannose, fucose, and bacterial polysaccharides containing mannose as the immunodominant sugar are particularly effective in inhibiting cytotoxic antibodies.

Type

Journal article

Journal

Tissue Antigens

Publication Date

07/1976

Volume

8

Pages

21 - 28

Keywords

ABO Blood-Group System, Animals, Antibodies, Antibody Specificity, Cell Line, Cytotoxicity Tests, Immunologic, Fucose, Glycopeptides, Immunoglobulin M, Immunoglobulin lambda-Chains, Immunoglobulin mu-Chains, Lewis Blood-Group System, Mannose, Monosaccharides, Neuraminidase, Polysaccharides, Bacterial, Rabbits