Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A series of restriction fragment length polymorphisms which are due to DNA rearrangements have been identified within two highly variable regions flanking the human alpha globin genes. The existence of such highly polymorphic areas provides a large number of individual genetic markers for the alpha globin gene cluster on chromosome 16. If, as seems likely, such regions occur frequently throughout the human genome they should be of considerable value in the antenatal diagnosis of genetic disease.

Original publication

DOI

10.1093/nar/9.17.4213

Type

Journal article

Journal

Nucleic acids research

Publication Date

09/1981

Volume

9

Pages

4213 - 4224

Keywords

Chromosomes, Human, 16-18, Humans, Thalassemia, DNA Restriction Enzymes, Deoxyribonucleases, Type II Site-Specific, Deoxyribonuclease BamHI, Globins, DNA, Genetic Markers, Polymorphism, Genetic