The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.
Adult, Alleles, Antibodies, Viral, Asians, Chemokine CCL2, China, Female, Gene Frequency, Genes, Recessive, Genetic Predisposition to Disease, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Male, Membrane Proteins, Models, Genetic, Odds Ratio, Polymorphism, Single Nucleotide, RNA-Binding Proteins, Severity of Illness Index, Young Adult