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Colorectal tumours harbour a sub-population of cells with stem like properties termed 'cancer stem cells', which are believed to ultimately drive cancer growth. This review discusses recent advances in our understanding of both normal and cancer intestinal stem cells, with emphasis on similarities and differences. Specifically we discuss the role of the Wnt, Notch and BMP pathways and their roles in both stem cell proliferation and differentiation. Furthermore we discuss the emerging role of microRNA and the influence of environmental factors such as tumour associated myofibroblasts and hypoxia on cancer stem cell regulation.

Original publication

DOI

10.1016/j.canlet.2012.04.016

Type

Journal article

Journal

Cancer lett

Publication Date

10/09/2013

Volume

338

Pages

120 - 126

Keywords

BMP, Colon, Differentiation, Hypoxia, Myofibroblasts, Notch, Regulation, Stem cells, Wnt, Bone Morphogenetic Proteins, Gene Expression Regulation, Neoplastic, Humans, Intestinal Neoplasms, Models, Genetic, Neoplastic Stem Cells, Receptors, Notch, Signal Transduction, Tumor Microenvironment, Wnt Signaling Pathway