Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Although hypoxia is widely associated with adult pathologies such as cancer, it is also a physiological process that regulates cell differentiation during organogenesis. In an attempt to characterize the molecular mechanisms that are involved in hypoxia-regulated cell fate, a recent publication by Gustafsson and colleagues elegantly demonstrated that hypoxia blocks cell differentiation through the regulation of Notch signalling. This study showed that hypoxia-inducible factor (HIF)-1alpha interacts and acts in synergy with the Notch intracellular domain (NIC) and subsequently activates transcription of Notch targets. The identification of this crosstalk between pathways that are often deregulated in cancer is groundbreaking and opens up new areas for cancer research.

Original publication

DOI

10.1016/j.molmed.2006.02.001

Type

Journal article

Journal

Trends Mol Med

Publication Date

04/2006

Volume

12

Pages

141 - 143

Keywords

Animals, Cell Differentiation, Cell Hypoxia, Humans, Hypoxia-Inducible Factor 1, Models, Biological, Receptors, Notch, Signal Transduction