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Interleukin 17 (IL-17)-producing T helper cells (T(H)-17 cells) have been characterized in mice as a distinct subset of effector cells, but their identity and properties in humans remain elusive. We report here that expression of CCR6 and CCR4 together identified human memory CD4+ T cells selectively producing IL-17 and expressing mRNA encoding the human ortholog of mouse RORgammat, a transcription factor, whereas CCR6 and CXCR3 identified T(H)1 cells producing interferon-gamma and T helper cells producing both interferon-gamma and IL-17. Memory T cells specific for Candida albicans were present mainly in the CCR6+CCR4+ T(H)-17 subset, whereas memory T cells specific for Mycobacterium tuberculosis were present in CCR6+CXCR3+ T helper type 1 subset. The elicitation of IL-17 responses correlated with the capacity of C. albicans hyphae to stimulate antigen-presenting cells for the priming of T(H)-17 responses in vitro and for the production of IL-23 but not IL-12. Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens.

Original publication

DOI

10.1038/ni1467

Type

Journal article

Journal

Nat immunol

Publication Date

06/2007

Volume

8

Pages

639 - 646

Keywords

Animals, Antigens, Candida albicans, Cells, Cultured, Gene Expression Regulation, Humans, Immunologic Memory, Interleukin-17, Interleukin-23, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Phenotype, RNA, Messenger, Receptors, CCR4, Receptors, CCR6, Receptors, CXCR3, Receptors, Chemokine, Receptors, Retinoic Acid, Receptors, Thyroid Hormone, T-Lymphocytes, Helper-Inducer