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Two early papers expressing conflicting views on the occurrence of effective immune attack against cancers stimulate an analysis of the gradual development of an understanding of tumour biology. This understanding has led to the development of the strikingly effective check point blocking and CART anti-cancer immunotherapies, and the promise of more widely applicable therapies based on T cell attracting genetically engineered monoclonal antibodies.

Original publication




Journal article


British journal of cancer

Publication Date



Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford, UK.