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MicroRNAs (miRs) are short non-coding transcripts involved in a wide variety of cellular processes. Several recent studies have established a link between hypoxia, a well-documented component of the tumour microenvironment, and specific miRs. One member of this class, miR-210, was identified as hypoxia inducible in all the cell types tested, and is overexpressed in most cancer types. Its hypoxic induction is dependent on a functional hypoxia-inducible factor (HIF), thus extending the transcriptional repertoire of the latter beyond 'classic' genes. From a clinical standpoint, miR-210 overexpression has been associated with adverse prognosis in breast tumours and been detected in serum of lymphoma patients and could serve as a tool to define hypoxic malignancies. We discuss the role of miR-210 and its emerging targets, as well as possible future directions for clinical applications in oncology and ischaemic disorders.

Original publication

DOI

10.1111/j.1582-4934.2008.00398.x

Type

Journal article

Journal

J Cell Mol Med

Publication Date

09/2008

Volume

12

Pages

1426 - 1431

Keywords

Animals, Gene Expression Regulation, Humans, Hypoxia, Hypoxia-Inducible Factor 1, alpha Subunit, MicroRNAs, Transcription Factors