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The lack of oxygen delivery to tumor cells has profound consequences for tumor growth and correlates with poor prognosis. Some tumors contain regions of very severe hypoxia called anoxia, which constitutes a functionally different state to hypoxia. In response to anoxia, mammalian cells induce coordinated cytoprotective programs that are critical for tumor survival: the unfolded protein response and integrated stress response. Therefore, targeting additional components of anoxic pathways, besides the hypoxia-inducible response, may be effective for future anticancer therapies.

Original publication

DOI

10.1158/1078-0432.CCR-06-2126

Type

Journal article

Journal

Clin Cancer Res

Publication Date

01/05/2007

Volume

13

Pages

2537 - 2540

Keywords

Activating Transcription Factor 4, Endoplasmic Reticulum, Humans, Hypoxia, Neoplasm Proteins, Neoplasms, Protein Biosynthesis, Protein Folding, Transcription, Genetic, eIF-2 Kinase