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Notch signaling is an evolutionarily conserved pathway that regulates numerous physiological processes. Disruption of Notch has been implicated in multiple tumor types. Evidence from in vitro experiments, mouse models and human tumor samples indicates that Notch plays a predominantly oncogenic role in breast cancer and interacts with other pathways involved in tumorigenesis. In addition, Notch signaling is required for physiological angiogenesis and may promote tumor angiogenesis. A variety of strategies for blocking Notch signaling, in particular gamma-secretase inhibition, are discussed as potential therapies for breast cancer and tumor angiogenesis.

Original publication

DOI

10.1007/s10911-006-9011-7

Type

Journal article

Journal

J Mammary Gland Biol Neoplasia

Publication Date

01/2006

Volume

11

Pages

41 - 52

Keywords

Amyloid Precursor Protein Secretases, Animals, Antineoplastic Agents, Breast Neoplasms, Female, Humans, Neovascularization, Pathologic, Receptor Cross-Talk, Receptors, Notch, Signal Transduction