Genotoxic aldehydes in the hematopoietic system.

Wang M., Dingler FA., Patel KJ.

Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem cells and blood production. To protect against aldehydes, mammals have evolved a family of enzymes to detoxify aldehydes, and the Fanconi anemia DNA repair pathway to process aldehyde-induced DNA damage. Loss of either protection mechanisms in humans results in defective hematopoiesis and predisposition to leukemia. This review will focus on the impact of genotoxic aldehydes on hematopoiesis, the sources of endogenous aldehydes, and potential novel protective pathways.

DOI

10.1182/blood.2019004316

Type

Journal article

Journal

Blood

Publication Date

07/04/2022

Volume

139

Pages

2119 - 2129

Keywords

Aldehydes, Animals, DNA Damage, Fanconi Anemia, Hematopoiesis, Hematopoietic Stem Cells, Humans, Mammals

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