Interferon induction held captive in tumor cells.

Bridgeman A., Rehwinkel J.

Unusual nucleic acids activate innate immunity and may be present in transformed cells. Meng et al. (2021) find that cancer-associated mutations in NF2 turn this tumor suppressor into a potent antagonist of DNA- and RNA-induced innate immune signaling.

DOI

10.1016/j.molcel.2021.10.004

Type

Journal article

Journal

Mol Cell

Publication Date

21/10/2021

Volume

81

Pages

4109 - 4110

Keywords

Immunity, Innate, Interferons, Nucleic Acids, RNA, Signal Transduction

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