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Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is involved in cell differentiation, proliferation, and apoptosis, and was recently shown to be regulated by hypoxia. The present immunohistochemical study demonstrates extensive nuclear expression of the protein in 38% of a series of 115 non-small cell lung carcinomas using a polyclonal antibody (Ab) recognizing DEC1 protein. Such expression was directly related to the expression of two hypoxia-regulated proteins, namely the hypoxia-inducible factor (HIF) 1alpha and carbonic anhydrase-9. Although DEC1 was not related to angiogenesis or to the expression of VEGF and thymidine phosphorylase, a direct association with up-regulated bFGF receptors was noted. DEC1 was persistently expressed in the nuclei of normal bronchial and alveolar tissue. It is suggested that loss of DEC1 expression is an early event in the development of lung cancer, while DEC1 gene expression occurs in a subset of tumours and parallels the overexpression of other hypoxia-regulated proteins.

Original publication

DOI

10.1002/path.1330

Type

Journal article

Journal

J Pathol

Publication Date

06/2003

Volume

200

Pages

222 - 228

Keywords

Adult, Aged, Antigens, Neoplasm, Basic Helix-Loop-Helix Transcription Factors, Biomarkers, Tumor, Carbonic Anhydrase IX, Carbonic Anhydrases, Carcinoma, Non-Small-Cell Lung, Cell Hypoxia, DNA-Binding Proteins, Endothelium, Vascular, Female, Homeodomain Proteins, Humans, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, Lung, Lung Neoplasms, Male, Middle Aged, Multivariate Analysis, Neoplasm Proteins, Neovascularization, Pathologic, Nuclear Proteins, Prognosis, Survival Analysis, Transcription Factors