A multicenter comparative acute myeloid leukemia study: can we explain the differences in the outcomes in resource-constrained settings?

Silveira DRA., Coelho-Silva JL., Silva WF., Vallance G., Pereira-Martins DA., Madeira MIA., Figueredo-Pontes LL., Velloso EDRP., Simões BP., Peniket A., Danby R., Rego EM., Vyas P., Traina F., Bendit I., Quek L., Rocha V.

Outcomes in acute myeloid leukemia (AML) are dependent on patient- and disease-characteristics, treatment, and socioeconomic factors. AML outcomes between resource-constrained and developed countries have not been compared directly. We analyzed two cohorts: from São Paulo state, Brazil (USP, n = 312) and Oxford, United Kingdom (OUH, n = 158). USP cohort had inferior 5-year overall survival compared with OUH (29% vs. 49%, adjusted-p=.027). USP patients have higher early-mortality (23% vs. 6% p

DOI

10.1080/10428194.2020.1827252

Type

Journal article

Journal

Leuk Lymphoma

Publication Date

01/2021

Volume

62

Pages

147 - 157

Keywords

Acute myeloid leukemia, early mortality, infection, stem-cell transplant, survival, Brazil, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Myeloid, Acute, Retrospective Studies, United Kingdom

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