Modelling multiscale aspects of colorectal cancer
Van Leeuwen IMM., Byrne HM., Johnston MD., Edwards CM., Chapman SJ., Bodmer WF., Maini PK.
Colorectal cancer (CRC) is responsible for nearly half a million deaths annually world-wide . We present a series of mathematical models describing the dynamics of the intestinal epithelium and the kinetics of the molecular pathway most commonly mutated in CRC, the Wnt signalling network. We also discuss how we are coupling such models to build a multiscale model of normal and aberrant guts. This will enable us to combine disparate experimental and clinical data, to investigate interactions between phenomena taking place at different levels of organisation and, eventually, to test the efficacy of new drugs on the system as a whole. © 2008 American Institute of Physics.