Tasaduq Hussain Wani
DNA damage response (DDR) activities are controlled and regulated by post-translational modifications (PTMs) in a very co-ordinated manner. The repair pathways rely on phosphorylation of proteins to regulate DNA repair by aiding in recognition, initiation, recruitment and maintenance of repair mechanisms. Owing to their frequency and functional consequences phosphosites, thus are the most important PTMs. My research interests include exploration of DDR in the context of such PTMs.
I studied Biochemistry for my BSc and MSc at University of Kashmir before starting my PhD at Shiv Nadar University in India. My doctoral research was themed on deducing the mechanism of DNA damage by quinone based targeted anti-tumor agents. Major focus was on YM155, used in breast cancers and on controversial thalidomide, used in multiple myeloma. Explicitly, this work established that interference with DNA damage response can help overcome adaptive resistance in tumours. Following my PhD, I joined the Blackford Lab as a postdoctoral researcher in September 2020.