Marieke Oudelaar

PhD

Junior Research Fellow

My research focuses on the mechanisms by which the regulatory elements of the genome control tissue-specific gene expression patterns. In particular, I am interested in the relationship between the structural, three-dimensional organisation of the genome in the nucleus and the regulation of gene expression. My main goals are to understand how regulatory elements interact within nuclear chromatin structures, when and how such structures are established during development, and how disruptions of these structures cause mis-regulation of gene expression and contribute to human disease.

Key publications

A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells.
Journal article

Chiariello AM. et al, (2020), Cell Rep, 30, 2125 - 2135.e5
A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus.
Journal article

Oudelaar AM. et al, (2019), Nat Commun, 10
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.
Journal article

Oudelaar AM. et al, (2018), Nat Genet, 50, 1744 - 1751
Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.
Journal article

Oudelaar AM. et al, (2017), Nucleic Acids Res, 45
Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells.
Journal article

Oudelaar AM. et al, (2017), Bio Protoc, 7
Between form and function: the complexity of genome folding.
Journal article

Oudelaar AM. et al, (2017), Hum Mol Genet, 26, R208 - R215
Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.
Journal article

Hanssen LLP. et al, (2017), Nat Cell Biol, 19, 952 - 961
How best to identify chromosomal interactions: a comparison of approaches.
Journal article

Davies JOJ. et al, (2017), Nat Methods, 14, 125 - 134