Contact information
Colleges
Marieke Oudelaar
PhD
Junior Research Fellow
My research focuses on the mechanisms by which the regulatory elements of the genome control tissue-specific gene expression patterns. In particular, I am interested in the relationship between the structural, three-dimensional organisation of the genome in the nucleus and the regulation of gene expression. My main goals are to understand how regulatory elements interact within nuclear chromatin structures, when and how such structures are established during development, and how disruptions of these structures cause mis-regulation of gene expression and contribute to human disease.
Key publications
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A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells.
Journal article
Chiariello AM. et al, (2020), Cell Rep, 30, 2125 - 2135.e5
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A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus.
Journal article
Oudelaar AM. et al, (2019), Nat Commun, 10
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Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.
Journal article
Oudelaar AM. et al, (2018), Nat Genet, 50, 1744 - 1751
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Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.
Journal article
Oudelaar AM. et al, (2017), Nucleic Acids Res, 45
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Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells.
Journal article
Oudelaar AM. et al, (2017), Bio Protoc, 7
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Between form and function: the complexity of genome folding.
Journal article
Oudelaar AM. et al, (2017), Hum Mol Genet, 26, R208 - R215
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Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.
Journal article
Hanssen LLP. et al, (2017), Nat Cell Biol, 19, 952 - 961
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How best to identify chromosomal interactions: a comparison of approaches.
Journal article
Davies JOJ. et al, (2017), Nat Methods, 14, 125 - 134