Background: Atopic dermatitis (AD) is an inflammatory cutaneous disorder. The advancements in the understanding of AD immunological pathogenesis have caused the development of therapies that suppress the dysregulated immune response. We aimed to evaluate the immunomodulatory effect of dental stem cells (dental follicle-mesenchymal stem cells [DF-MSCs]) on AD patients. Materials & methods: We investigated the immunoregulatory potential of DF-MSCs on T cell response in AD and compared them with psoriasis and healthy individuals and the underlying mechanisms. Results: DF-MSCs significantly reduced Fas, FasL and TNFR II frequency in T cells, increased naive T cell population while reducing memory T cell, decreased inflammatory cytokine levels and promoted Tregs frequency in the AD population. Conclusion: These results imply that DF-MSCs are modulating inflammation through decreasing T cell apoptosis, inducing Treg expansion and stabilizing cytokine levels.
Journal article
2021-07-01T00:00:00+00:00
13
825 - 840
15
atopic dermititis, dental follicle mesenchymal stem cells, immunomodulation, immunotherapy, psoriasis, regenarative medicine, Adolescent, Adult, Dental Sac, Dermatitis, Atopic, Female, Humans, Immunity, Immunomodulation, Male, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Treatment Outcome, Young Adult