Prof Irene Roberts and Prof Adam Mead, WIMM: The immunological landscape of JMML
Dr Anupama Rao, Great Ormond Street Hospital: The immunological landscape of JMML
Dr Graham Collins, OUH Haematology: Immune responses in Hodgkin lymphoma patients treated with checkpoint inhibitors
Prof GS Besra, University of Birmingham
Clinical Research Fellow
A senior scientist in the MRC Human Immunology Unit in Oxford, with a strong interest in innate and adaptive immunity and a focus on unconventional T cell responses, CD1 and MR1 restricted. Aiming to harness the power of unconventional T cells to induce DC maturation and antigen specific adaptive immunity, to enhance immune responses to infections and cancer. Leveraging multiparameter high end cytometry data to understand immunological signatures predictive of response in cancer patients treated with immunomodulating agents.
I graduated in Medicine at the University of Torino, Italy, after spending some time as a visiting research student at Mount Sinai Medical School (New York) and Harvard Medical School (Boston). I then joined the lab of Prof Antonio Lanzavecchia at the Basel Institute for Immunology in 1996, to work on human Dendritic Cells, within the EUNIDI network (European Union Network for Investigation of Dendritic Cell Immunotherapy). I moved to Oxford at the end of 1999 and joined the group of Prof Vincenzo Cerundolo in the MRC Human Immunology Unit. My main research interest is understanding how Dendritic Cells, the specialized antigen presenting cells of the immune system orchestrate immune responses and efficiently prime antigen specific T cells. Specifically, I am interested in understanding how subset of immune cells known as innate-like T cells or unconventional T cells modulate Dendritic Cell activation. The two main subsets of innate like T cells I have been studying are CD1d-restricted iNKT cells and MR1-restricted MAIT cells, which recognize non-peptidic antigens.
To understand the molecular mechanisms of iNKT cell and MAIT cell activation and their cross-talk with Dendritic Cells, I use a range of cellular and molecular techniques, and I am particularly interested in developing multiparameter flow cytometry, using the BD X50 Symphony platform. In addition to understanding the fundamental biology of innate like T cells, I am investigating their role in disease setting, such as cancer. Because of their abundance in humans and their key location at mucosal sites, I am studying the function of CD1 and MR1 restricted T cells in modulating the anti tumour immune response in patients with haematological cancers.
I lecture students at the MSc in Integrated Immunology (NDS, Oxford) on unconventional T cells, with a focus on CD1 and MR1 restricted T cells. I also have an interest in Cancer Immunology, run ad hoc tutorials for Williams students at Exeter College and I am the Cancer Immunology module lead for the MSc in Precision Cancer Medicine (Department of Oncology, Oxford).
The P5-type ATPase ATP13A1 modulates major histocompatibility complex I-related protein 1 (MR1)-mediated antigen presentation
Kulicke CA. et al, (2021), Journal of Biological Chemistry, 101542 - 101542
CD1-MR1 EMBO workshop: Beyond MHC-restricted lymphocytes, Oxford September 2019.
Klenerman P. et al, (2021), Mol Immunol, 134, 170 - 171
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Ahern DJ. et al, (2021)
Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation.
Crump NT. et al, (2021), Cell Rep, 35
Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.
Frost JN. et al, (2021), Med (N Y), 2, 164 - 179.e12