EDGE ITN PhD Programme
Horizon 2020 Marie Sklodowska Curie Actions programme on Herpesvirus biology
BSc, MSc, DPhil
I am a PostDoc working in the group of Prof Jan Rehwinkel. My research focuses on the interplay between the innate immune system and herpes viruses that infect humans. For an organism to be able to mount an immune response against any pathogen, recognition of infection is crucial. In the context of viral infections, the main molecular pattern that is recognized as foreign by the host organism is viral nucleic acids. Most human cells encompass multiple proteins and pathways that can trigger an immune response after sensing nucleic acids that are abnormal in regards to either their biochemical composition or sub-cellular localisation. I am investigating which cellular proteins recognize what kind of herpes virus derived nucleic acids during the viral replication cycle. Furthermore, I am looking at mechanism by which herpes viruses suppress nucleic acid recognition in order to evade antiviral immune responses.
After receiving a Bachelor's degree in Molecular Medicine from the University of Göttingen in 2014, I worked as a consulting intern with McKinsey & Company to gain experience outside of academia. I obtained my MSc and DPhil degrees in Immunology from the University of Oxford in 2016 and 2019. My general research interest can be summarised as host-pathogen interactions in the context of viral infections.
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.
Lepelley A. et al, (2020), J Exp Med, 217
RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death.
Schilling M. et al, (2020), Cells, 9
Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS
Hertzog J. et al, (2020)
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.
Hertzog J. et al, (2018), Eur J Immunol, 48, 1120 - 1136
Six subgroups and extensive recent duplications characterize the evolution of the eukaryotic tubulin protein family.
Findeisen P. et al, (2014), Genome Biol Evol, 6, 2274 - 2288