MRC WIMM Group Leader
I received my MPhys in Theoretical Physics from the Universidad Autonoma de Madrid in Spain. Prior to starting my PhD I worked as a consultant in industry and held several research positions working on Nuclear Physics (Spanish National Research Council), Theoretical Neuroscience (Theoretical Physics Department UAM) and Computational Biology (Spanish National Cancer Research Centre). I completed my PhD in Warwick University’s Systems Biology DTC where I worked on developing Bayesian methods to study large gene regulatory networks. After my PhD I moved to Cambridge where I was a Postdoctoral Fellow in Prof Simon Tavaré’s group at CRUK/Cambridge University. During my stay in Cambridge I developed an interest in cellular fate choices in mammalian tissues. Specifically, while in Cambridge, I developed mathematical models of stem cells in order to understand their stochastic behaviour and how this behaviour was altered by oncogenic mutations.
In November 2016 I moved to the Weatherall Institute to set up a Quantitative Biology group. The groups focus is to study cell fate choices, applying techniques such as Stochastic Modelling, Bayesian Inference and Deep Learning.
Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.
Nicholson AM. et al, (2018), Cell Stem Cell, 22, 909 - 918.e8
Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells.
Huels DJ. et al, (2018), Nat Commun, 9
Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth.
Singh SP. et al, (2017), Nat Commun, 8
Stem cell competition: how speeding mutants beat the rest.
Morrissey ER. and Vermeulen L., (2014), EMBO J, 33, 2277 - 2278
Mathematical Modelling of Murine Stem Cells in Intestinal Epithelium and Adenomas
Kozar S. et al, (2013), JOURNAL OF PATHOLOGY, 231, 26 - 26