DPhil research opportunity
MRC WIMM Group Leader and Principal Investigator in RDM
I received my MPhys in Theoretical Physics from the Universidad Autonoma de Madrid in Spain. Prior to starting my PhD I worked as a consultant in industry and held several research positions working on Nuclear Physics (Spanish National Research Council), Theoretical Neuroscience (Theoretical Physics Department UAM) and Computational Biology (Spanish National Cancer Research Centre). I completed my PhD in Warwick University’s Systems Biology DTC where I worked on developing Bayesian methods to study large gene regulatory networks. After my PhD I moved to Cambridge where I was a Postdoctoral Fellow in Prof Simon Tavaré’s group at CRUK/Cambridge University. During my stay in Cambridge I developed an interest in cellular fate choices in mammalian tissues. Specifically, while in Cambridge, I developed mathematical models of stem cells in order to understand their stochastic behaviour and how this behaviour was altered by oncogenic mutations.
In November 2016 I moved to the Weatherall Institute to set up a Quantitative Biology group. The groups focus is to study cell fate choices, applying techniques such as Stochastic Modelling, Bayesian Inference and Deep Learning.
The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.
Azzoni E. et al, (2021), Cell Rep, 37
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas.
Lodestijn SC. et al, (2021), Cell Stem Cell
A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes.
Harman JR. et al, (2021), Genome Res
Apc-mutant cells act as supercompetitors in intestinal tumour initiation.
van Neerven SM. et al, (2021), Nature, 594, 436 - 441
A diffusion-like process accommodates new crypts during clonal expansion in human colonic epithelium.
Olpe C. et al, (2021), Gastroenterology