DPhil research opportunity
MRC WIMM Group Leader
I received my MPhys in Theoretical Physics from the Universidad Autonoma de Madrid in Spain. Prior to starting my PhD I worked as a consultant in industry and held several research positions working on Nuclear Physics (Spanish National Research Council), Theoretical Neuroscience (Theoretical Physics Department UAM) and Computational Biology (Spanish National Cancer Research Centre). I completed my PhD in Warwick University’s Systems Biology DTC where I worked on developing Bayesian methods to study large gene regulatory networks. After my PhD I moved to Cambridge where I was a Postdoctoral Fellow in Prof Simon Tavaré’s group at CRUK/Cambridge University. During my stay in Cambridge I developed an interest in cellular fate choices in mammalian tissues. Specifically, while in Cambridge, I developed mathematical models of stem cells in order to understand their stochastic behaviour and how this behaviour was altered by oncogenic mutations.
In November 2016 I moved to the Weatherall Institute to set up a Quantitative Biology group. The groups focus is to study cell fate choices, applying techniques such as Stochastic Modelling, Bayesian Inference and Deep Learning.
Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-deficient Murine Epithelium.
Christopher J. et al, (2019), Genetics
Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.
Palii CG. et al, (2019), Cell Stem Cell, 24, 812 - 820.e5
Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts.
van der Heijden M. et al, (2019), Proc Natl Acad Sci U S A, 116, 6140 - 6145
Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer.
Lenos KJ. et al, (2018), Nat Cell Biol, 20, 1193 - 1202
Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration.
Tomic G. et al, (2018), Cell Stem Cell, 23, 436 - 443.e7