DPhil research opportunity
MRC WIMM Group Leader and Principal Investigator in RDM
I received my MPhys in Theoretical Physics from the Universidad Autonoma de Madrid in Spain. Prior to starting my PhD I worked as a consultant in industry and held several research positions working on Nuclear Physics (Spanish National Research Council), Theoretical Neuroscience (Theoretical Physics Department UAM) and Computational Biology (Spanish National Cancer Research Centre). I completed my PhD in Warwick University’s Systems Biology DTC where I worked on developing Bayesian methods to study large gene regulatory networks. After my PhD I moved to Cambridge where I was a Postdoctoral Fellow in Prof Simon Tavaré’s group at CRUK/Cambridge University. During my stay in Cambridge I developed an interest in cellular fate choices in mammalian tissues. Specifically, while in Cambridge, I developed mathematical models of stem cells in order to understand their stochastic behaviour and how this behaviour was altered by oncogenic mutations.
In November 2016 I moved to the Weatherall Institute to set up a Quantitative Biology group. The groups focus is to study cell fate choices, applying techniques such as Stochastic Modelling, Bayesian Inference and Deep Learning.
A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes.
Harman JR. et al, (2021), Genome Res
Apc-mutant cells act as supercompetitors in intestinal tumour initiation.
van Neerven SM. et al, (2021), Nature, 594, 436 - 441
A diffusion-like process accommodates new crypts during clonal expansion in human colonic epithelium.
Olpe C. et al, (2021), Gastroenterology
Spatiotemporal analysis of human intestinal development at single-cell resolution.
Fawkner-Corbett D. et al, (2021), Cell
Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing.
Thorsen A-S. et al, (2020), Dis Model Mech